Massimiliano Allegri's decision to rest several of his key stars backfired as Juventus lost ground in the Scudetto race with a shock 3-2 defeat at Sampdoria.
Paulo Dybala and Gianluigi Buffon were among several regulars left out of the starting XI and the Serie A champions paid the price as they conceded three second-half goals.
Gonzalo Higuain and Juan Cuadrado both failed to make the most of earlier chances to leave the door ajar for the home side.
Sampdoria needed no invitation to take advantage as Duvan Zapata crashed in a 52nd-minute header before Lucas Torreira fired home from outside the area to completely swing the momentum.
Gianmarco Ferrari appeared to have put the seal on an emphatic victory when he made it 3-0 with just over 10 minutes remaining, although the Bianconeri mounted a stoppage-time fightback as Higuain scored from the spot after Ivan Strinic was adjudged to have fouled substitute Douglas Costa.
Dybala had also come off the bench in a bid to rescue Allegri's side and the Argentina star fired in a quickfire second to set up a tense final few seconds, but the damage was done.
The defeat leaves Juve four points adrift of leaders Napoli and they could drop to third depending on Inter's result against Atalanta later on Sunday.
Higuain looked certain to open the scoring as early as the second minute when he latched on to Federico Bernadeschi's throughball, but a vital sliding challenge from Matias Silvestre did just enough to divert the shot wide.
Sampdoria were otherwise dealing comfortably with the visitors' occasional incursions, although they suffered a setback when Dennis Praet limped off following a heavy challenge from Stephan Lichtsteiner.
And the loss of the midfielder might have been compounded just beyond the half-hour had Cuadrado made the most of a one-on-one opportunity.
The winger was superbly sent through on goal by Higuain but, from a narrow angle, opted to shoot rather than pass and saw his powerful finish deflect almost inadvertently off Emiliano Viviano and around the far post.
Juventus' frustrations grew when their appeals for the VAR to adjudicate on a potential handball against Strinic were scuppered by the referee's half-time whistle.
Seven minutes later, they were trailing. Bernadeschi's wild attempted clearance from Fabio Quagliarella's cross hung in the air and Zapata rose above Lichtsteiner to head it beyond Wojciech Szczesny.
Allegri's side came close to falling further behind when Zapata race onto Quagliarella's reverse pass, but Szczesny was this time quick off his line to smother the chance.
Dybala was called from the bench shortly after the hour and almost had an immediate impact, the forward's close-range shot blocked amid a goalmouth scramble.
Juventus started to knock on the door with Viviano next required to tip the ball away from a stretching Sami Khedira, while Higuain's heavy pass ruined a promising counter-attack.
But, against the run of play, Sampdoria made their multiple reprieves count as Torreira speared an unstoppable strike into the bottom-left corner from outside the area after being set up by Gaston Ramirez.
Ferrari looked to have put a comprehensive seal on the three points when he turned in a close-range third from Quagliarella's clever pass in the 79th minute.
3 - Sampdoria have scored three times with the first four shots on target they have fired in this match. Fierce. #sampdoriajuventus— OptaPaolo (@OptaPaolo) November 19, 2017
The Bianconeri did rally at the death to score twice in the closing moments – Higuain converting from the spot and Dybala clinically picking out the bottom corner after an assist by Costa.
Those strikes heightened the nerves of the home fans, but it came too late to prevent a first defeat in six league away games for Juve, as Samp strengthened their position in the top six.
Key Opta Stats:
- Sampdoria's previous win against Juventus in Serie A came back in May 2013 (D1 L7 in the other games since).
- Samp's 26 points collected over the first 12 matches are an all-time record for the club in Serie A.
- Duvan Zapata has scored in back-to-back Serie A games against Juventus: his previous goal came in March when he was at Udinese.
- Lucas Torreira has scored three goals in his last three Serie A appearances after going without one in his previous 44 league matches.
- This was the first match in the current Serie A season where Juventus have not been ahead for a single minute.
- Sampdoria are now Paulo Dybala's joint-favourite opponent in Serie A along with Lazio (six goals).
17 de diciembre 2017
|Cook, Root fall as Australia close in on win|
|Knicks top Thunder in Anthony´s return to New York|
|Saunders outclasses Lemieux to retain title|
|Chiefs too good for Chargers, Lions win|
|Australia push further ahead in Perth|
|Kroos: Madrid don´t need added motivation for Clasico|
|Howe discussed Liverpool criticism with Begovic|
|Pellegrino: I can´t control Van Dijk future|
|Perez suggests Madrid unlikely to make January moves|
|Packers activate Rodgers for Panthers clash|
|Gonzalez bids emotional farewell to Dodgers|
|Liverpool scouts to thank for Salah capture, says Klopp|
|Substitutes made the difference - Simeone|
16 de diciembre 2017
|Sarri praises ´extraordinary´ Hamsik as Napoli go top of Serie A|
|Mutual trust at Man City is ´a dream´, says Guardiola|
|Thorley grabs four in Gloucester rout, Connacht trounce Brice|
|Stoger´s small changes getting Dortmund back on track|
|Atletico Madrid 1 Alaves 0: Substitute Torres breaks LaLiga duck to net winner|
|City defeat a ´good experience´ for Tottenham - Pochettino|
|Fury takes pop at ´carthorse´ Joshua|
|Zidane dreaming of sextuple after Club World Cup success|
|Running man De Bruyne makes it easier to manage City - Guardiola|
|Ronaldo and Zidane hoping for Ballon d´Or winner to retire at Madrid|
|Championship Review: Teenage debutant Maja snaps Sunderland´s home drought|
|In-form Neymar is good for all who love football – Emery|
|Napoli´s record goalscorers - how Marek Hamsik compares to Diego Maradona|
|Leinster rally to beat Chiefs, Bath gain revenge over Toulon|
|De Bruyne eyes titles over unbeaten season|
|Ninja Turtles invade pitch during PSG clash|
|Muller, Heynckes buoyed by Bayern Munich´s edgy victory|
|I´m confident, but what does that mean? - Wenger gives cryptic answer on Ozil future|
|Real Madrid win five trophies in a calendar year for first time|
|It´s nice to know - Hamsik plays down matching Maradona´s Napoli record|
|Borussia Dortmund 2 Hoffenheim 1: Pulisic late show extends perfect Stoger start|
|Manchester City 4 Tottenham 1: Silva-less City continue to set the gold standard|
|Hughes fumes at Lanzini ´dive´|
|Torino 1 Napoli 3: Historic Hamsik strike sends Sarri´s side top|
|Dyche credits Burnley´s resolve in battling Brighton draw|
|Conte refuses to discuss Chelsea interest in ´really good player´ Van Dijk|
|Real Madrid 1 Gremio 0: Ronaldo free-kick secures Club World Cup glory|
|Silva refuses to question Watford´s attitude amid dismal run|
|Wenger hails Ozil´s decisive ´gem´|
|City´s record run unfairly overshadowing Chelsea form - Conte|
|Murray ´normally very reliable´ from the spot - Hughton|
|Stoke City 0 West Ham 3: Returning Arnautovic has the last laugh|
|Rennes 1 Paris Saint-Germain 4: Two goals, two assists for Neymar|
|Hamsik matches Maradona´s all-time Napoli scoring record|
|Apologetic Spalletti had forgotten losing feeling at Inter|
|We stick to the plan – Valverde not risking Dembele before January|
|Watford 1 Huddersfield Town 4: Deeney sees red as Hornets´ slump continues|
|Chelsea 1 Southampton 0: Alonso extends Blues´ home run|
|Arsenal 1 Newcastle United 0: Ozil stunner sees hosts edge back to winning ways|
|Brighton and Hove Albion 0 Burnley 0: Murray pays the penalty for Seagulls|
|McGregor says MMA, not Pacquiao, is next on agenda|
|Stuttgart 0 Bayern Munich 1: Ulreich denies former club with last-gasp penalty save|
|Gattuso tries to shrug off Donnarumma, FFP controversies|
|Inter 1 Udinese 3: Leaders leave door open for Napoli as unbeaten run ends|
|Al Jazira 1 Pachuca 4: Jara & Sagal inspire Mexicans to Club World Cup third place|
|Benteke winning over Palace fans after penalty nightmare - Hodgson|
|Allegri defends ´extraordinary´ Dybala after Nedved criticism|
|I didn´t owe Palace team-mates, Benteke claims|
|Carmelo Anthony ready for MSG return, calls New York ´home´|
|Five (not altogether serious) ways for England to avoid Ashes whitewash|
|I´ve never considered leaving PSG, insists Draxler|
|Leicester City 0 Crystal Palace 3: Benteke, Eagles end drought|
|AC Milan´s Fassone requests UEFA help over FFP|
|AC Milan have ´no intention´ of selling Donnarumma|
|Bravo sees no way back into West Indies set-up|
|Reggie Bush ´done´ with NFL career|
|A-League Review: Jets keep up pressure, Wanderers get rare win|