Andy Murray and Stan Wawrinka were bundled out of the Monte-Carlo Masters on Thursday, but Novak Djokovic and Rafael Nadal reached the quarter-finals in contrasting fashion.
Albert Ramos-Vinolas fought back from 4-0 down in the final set to claim the scalp of top seed Murray, who went down 2-6 6-2 7-5 on the clay in the principality.
The world number one was not the only big name to bow out, as US Open champion Wawrinka was beaten 6-4 6-4 by Pablo Cuevas.
Twelve-time grand slam champion Djokovic showed he still has work to do in order to return to the peak of his powers, but saw off Pablo Carreno Busta 6-2 4-6 6-4.
Fourth seed and defending champion Nadal only needed 68 minutes to beat birthday boy Alexander Zverev 6-1 6-1.
MURRAY RUES 'BAD DECISIONS'
Murray looked bound for the last eight when he won the first four games of the deciding set, but the three-time grand slam champion was left stunned by a defiant Ramos-Vinolas.
The top seed grew increasingly disgruntled in the final set as Spaniard Ramos-Vinolas turned the tide to seal the biggest victory of his career and book a last-eight meeting with Marin Cilic.
Wimbledon champion Murray said: "A few times, I made some bad decisions. That's something that, with my team, I'll look at, watch some parts of the match over, see the shots that I chose and what I would do differently."
WOE FOR WAWRINKA
Cuevas had never beaten a top-four player before stepping out on court against Wawrinka, but needed just the two sets to put that record right.
The 16th seed from Uruguay did not face a solitary break point against the three-time grand slam champion in the first meeting between the two.
DJOKOVIC PASSES CARRENO BUSTA TEST
Djokovic was in danger of following Murray and Wawrinka out of the tournament, but hung in there to get past a defiant Carreno Busta and seal a clash with David Goffin.
It looked set to be plain sailing for the world number two when he won six games in a row to lead 2-0 in the second set, but the Spaniard was not finished yet.
Djokovic lost the next five games before Carreno Busta took it into a decider and the underdog had the Serb in trouble at 15-40 and 4-4 in the final set, but was unable to pull off a shock.
NADAL SPOILS THE PARTY
Nine-time Monte Carlo champion Nadal did not come bearing gifts on Zverev's 20th birthday, racing to victory in a one-sided contest.
The Spanish great broke five times as he won at a canter and will now face Diego Schwartzman, who reaches his first Masters quarter-final with a 6-3 6-0 demolition of Jan-Lennard Struff.
Lucas Pouille will take on Cuevas after the Frenchman was given an easy passage into the last eight, with compatriot Adrian Mannarino retiring due to a hip injury early in the first set.
25 de septiembre 2017
|Marcelino laughs off injury after hurting hamstring celebrating|
|Diamondbacks clinch home-field advantage in wildcard game with walk-off win|
|Brady, Rodgers inspire comebacks for Pats and Packers|
|Milan shouldn´t be losing to weaker teams – Fassone slams Montella´s men|
|MLS Review: Sporting KC, Portland keep pressure on|
|Bautista receives emotional farewell from Blue Jays fans|
|It´s been a wild ride - Schauffele revels in Tour Championship victory|
|Mixed feelings for FedEx Cup champ Thomas, despite collecting $10m bonus|
|Wenger unwilling to sacrifice any potential trophy|
|Kershaw breaks Dodgers record for most seasons with 200 strikeouts|
|NFL players react to Trump´s ´assault´ on freedom of speech|
|Kane worth more than £100m – Noble|
|Klopp: I could write a book on defending|
|Maddon all for self-expression as Cubs manager clarifies Trump comments|
|Stanley Cup champions Penguins will visit White House|
|Kyle Busch advances to NASCAR playoffs with New Hampshire win|
|Ederson wishes Mane well after recovering from horror tackle|
|Schauffele wins Tour Championship, Thomas claims FedEx Cup title|
24 de septiembre 2017
|Axar returns for final two Australia ODIs|
|Guardiola balks at Chelsea or United fearing in-form Manchester City|
|Morata shining as Chelsea´s leading man after Juve, Madrid frustration|
|Black Caps omit Neesham and Broom for India ODI series|
|CAF Champions League Review: Etoile Sahel see off Al Ahli Tripoli to reach semi-finals|
|Moeen ´just had a slog´ in breathtaking century|
|Seahawks & Titans sit out national anthem|
|President Trump responds to anthem protests: Locked arms is good, kneeling is not acceptable|
|WATCH: Showboating costly as Bears´ Cooper is denied TD|
|Late Isa snatches Toulon win, Lyon up to third|
|Federer secures Laver Cup victory for Europe|
|Dzumhur sees off Fognini for history-making ATP triumph|
|Brighton winner was a foul, claims frustrated Benitez|
|Bjerregaard claims maiden European Tour title at Portugal Masters|
|Steelers skip anthem, players kneel as NFL shows solidarity amid Trump criticism|
|Brutal Moeen century sets up thumping England win|
|India wrap up series win over Australia and regain top spot in ODI rankings|
|Exeter Chiefs cruise to first place, Northampton Saints hammer London Irish|
|Spalletti: Unbeaten Inter must go beyond their limits|
|Brighton and Hove Albion 1 Newcastle United 0: Hemed the hero in second home win|
|Pedrosa unimpressed with incredible Rossi|
|Better late than never - Matuidi delighted with start to life at Juventus|
|Gojowczyk upsets Paire to win maiden ATP title at Moselle Open|
|Mladenovic´s miserable run continues in Wuhan|
|Sensational Sagan storms to third successive World crown|
|Inter 1 Genoa 0: Late D´Ambrosio header snatches victory for Spalletti´s side|
|Delph a willing deputy for injured City left-back Mendy|
|Tom Brady and Aaron Rodgers post messages of ´unity´ as unprecedented NFL Sunday dawns|
|Ravens and Jaguars players kneel, lock arms together for anthem at London game|
|Howedes ruled out for four weeks|
|Milan lacked determination and quality in Samp defeat - Montella|
|Sheffield Wednesday 2 Sheffield United 4: Clarke at the double in derby win|
|Uruguayan Primera Division fixtures cancelled amid referee strike|
|Marquez pulls clear with Aragon win as Rossi claims remarkable fifth|
|Patriots owner Robert Kraft, a Trump ally, ´deeply disappointed´ by president´s tone|
|Billy Vunipola sidelined for four months|
|Mendy hoping to follow successful City season with World Cup triumph|
|Sampdoria 2 AC Milan 0: Duvan Zapata claims family bragging rights|
|Dybala backs dropped Higuain to rediscover clinical touch|
|President Donald Trump continues shots at NFL in Sunday morning tweets|
|WATCH: Injured Rossi survives practice shunt|
|21st century boy - Lyon youngster Geubbels makes Ligue 1 history|
|Jones: England looking for a rookie with X-factor|
|Sensational Kipchoge storms to Berlin victory|
|Napoli fear more knee surgery for Milik|
|Spalletti promises reaction from smarting Inter|
|Beale eyes morale-boosting Bloemfontein win|
|Hughie Fury would wipe the floor with Anthony Joshua, says promoter|
|Montella backs ´fired up´ AC Milan to ´raise the bar´|
|French Open champion Ostapenko seals second career title in Seoul|
|Meunier: PSG don´t have Neymar dependency|
|Brewers claim walk-off win over Cubs|