Andy Murray and Stan Wawrinka were bundled out of the Monte-Carlo Masters on Thursday, but Novak Djokovic and Rafael Nadal reached the quarter-finals in contrasting fashion.
Albert Ramos-Vinolas fought back from 4-0 down in the final set to claim the scalp of top seed Murray, who went down 2-6 6-2 7-5 on the clay in the principality.
The world number one was not the only big name to bow out, as US Open champion Wawrinka was beaten 6-4 6-4 by Pablo Cuevas.
Twelve-time grand slam champion Djokovic showed he still has work to do in order to return to the peak of his powers, but saw off Pablo Carreno Busta 6-2 4-6 6-4.
Fourth seed and defending champion Nadal only needed 68 minutes to beat birthday boy Alexander Zverev 6-1 6-1.
MURRAY RUES 'BAD DECISIONS'
Murray looked bound for the last eight when he won the first four games of the deciding set, but the three-time grand slam champion was left stunned by a defiant Ramos-Vinolas.
The top seed grew increasingly disgruntled in the final set as Spaniard Ramos-Vinolas turned the tide to seal the biggest victory of his career and book a last-eight meeting with Marin Cilic.
Wimbledon champion Murray said: "A few times, I made some bad decisions. That's something that, with my team, I'll look at, watch some parts of the match over, see the shots that I chose and what I would do differently."
WOE FOR WAWRINKA
Cuevas had never beaten a top-four player before stepping out on court against Wawrinka, but needed just the two sets to put that record right.
The 16th seed from Uruguay did not face a solitary break point against the three-time grand slam champion in the first meeting between the two.
DJOKOVIC PASSES CARRENO BUSTA TEST
Djokovic was in danger of following Murray and Wawrinka out of the tournament, but hung in there to get past a defiant Carreno Busta and seal a clash with David Goffin.
It looked set to be plain sailing for the world number two when he won six games in a row to lead 2-0 in the second set, but the Spaniard was not finished yet.
Djokovic lost the next five games before Carreno Busta took it into a decider and the underdog had the Serb in trouble at 15-40 and 4-4 in the final set, but was unable to pull off a shock.
NADAL SPOILS THE PARTY
Nine-time Monte Carlo champion Nadal did not come bearing gifts on Zverev's 20th birthday, racing to victory in a one-sided contest.
The Spanish great broke five times as he won at a canter and will now face Diego Schwartzman, who reaches his first Masters quarter-final with a 6-3 6-0 demolition of Jan-Lennard Struff.
Lucas Pouille will take on Cuevas after the Frenchman was given an easy passage into the last eight, with compatriot Adrian Mannarino retiring due to a hip injury early in the first set.
21 de noviembre 2017
|Griezmann: I don´t regret staying at Atletico|
|Rogers tells Paine to enjoy Ashes: It´s just a game!|
|Warner ready for first Ashes Test despite neck injury|
|Ashes newcomer Bancroft thought Test chance was gone - Voges|
|Warner suffers injury scare ahead of Ashes|
|Guardiola dismisses Champions League favourites tag|
|Jackson excited about Gordon´s return: I get to open a new toy|
|Nuggets head coach Malone suspended for one game|
|Steelers OT Gilbert handed four-game PED suspension|
|Prior hits back at ´ridiculous´ claims as Lyon hopes Australia end careers|
20 de noviembre 2017
|Dolphins QB Cutler placed in concussion protocol|
|Navratilova leads tributes to ´amazing´ Novotna after her death at 49|
|Brighton and Hove Albion 2 Stoke City 2: Gross, Izquierdo extend home unbeaten run|
|Dimitrov braced for Australian Open expectations|
|Broncos fire offensive coordinator Mike McCoy|
|England won´t suffer Gabba ambush, Malan claims|
|Rose in contention to face Dortmund as Pochettino denies ´issue´ with defender|
|Benzema knows he can give more – Zidane|
|I´ve fulfilled my dreams already – Klopp has no plans to coach Barcelona|
|Memorable Ashes Moments: Unlikely saviour Agar falls agonisingly short|
|Wallabies coach Cheika faces investigation|
|The Ashes: Australia squad profiles|
|Aubameyang will face Tottenham, Bosz confirms|
|Klopp expects Matip to face Chelsea, Lallana return getting ´nearer´|
|Brown could return for England, Underhill out|
|Haye´s rematch with Bellew off due to bicep tear|
|The Ashes: England squad profiles|
|Gatland vows not to rise to New Zealand media barbs|
|Berizzo looking to former Red Aspas to provide lessons for Sevilla|
|Mangala ready to pounce, but realistic on Man City playing time|
|The Ashes: How the urn will be won - the case for Australia and England|
|Innovation key as WTA Media embraces evolving viewing habits|
|Trump calls for Lynch to be suspended as anthem row returns|
|Mendy injury means Aguero or Jesus for Guardiola|
|Kohli proud of India after almost snatching Kolkata win|
|The Ashes: Key contests in the battle for the urn|
|Guardiola sends ´big hug´ to ´amazing, so gentle´ Pulis|
|Tavecchio quits as head of FIGC, claims board have refused to resign|
|Benedetto facing Argentina World Cup KO with cruciate injury|
|Hansen hails All Blacks progress|
|Kohli´s record century precedes Bhuvneshwar heroics, but Sri Lanka cling on|
|Shape up! Heynckes reveals demand to Bayern star Vidal|
|Australia hope to open England ´scars´ in Brisbane|
|Smiling Broad sports bruise after golfing mishap|
|Ramos sits out Madrid trip to APOEL|
|West Brom sack Pulis after wretched run|
|Ball fighting fit ahead of Ashes opener at the Gabba|
|Murray should appoint Delgado as Lendl replacement - Henman|
|Former Wimbledon champion Novotna dies aged 49|
|Lloris wants Spurs to forget title and focus on top four|
|Pogba no Gerrard yet, says Benitez|
|Pearce released from Roosters contract|
|Expect to get six ducks – Paine reveals Rogers´ Ashes advice|
|Lyon: I don´t care if Stokes plays Ashes|
|Curry´s offensive explosion leads Warriors past Nets|
|Ball records second triple-double to join Magic, West in record books|
|Patriots, Ravens win among multiple blowouts|
|Flyers´ Gudas suspended for 10 games for violent slash|
|Two-time NBA All-Star David Lee announces retirement|
|Guardiola will ´kill´ City stars if they get complacent|
|Bills coach McDermott to ´evaluate´ quarterback position|
|LeBron on Kaepernick controversy: I don´t respect the NFL|
|Ibrahimovic: My injury was worse than people know|
|Russell to leave Warriors at end of season|
|Cook cruises to first PGA Tour win|
|Truex wins first NASCAR championship|
|Cardinals´ Fitzgerald now fifth all-time in receiving yards|
|Icardi like a ´raptor pouncing on its prey´, says Spalletti|
19 de noviembre 2017
|Tired Goffin insists: ´I will be ready for Davis Cup final´|
|In-form Chelsea have regained hunger - Conte|